Wyn George was born in Wales. He had a natural affinity with the rugged Celtic landscape of the south west peninsula, especially Cornwall, the subject and inspiration of his work. He exhibited with Newlyn and St Ives Societies of Artists.

Wyn George was a student at Cardiff School of Art from 1927 to 1931 and obtained a teaching qualification at the Central School in London. He undertook various teaching posts before serving in World War II as a navigation officer in the Royal Navy. This experience provided the source of some of his best post-war painting. From 1948 to 1974 he was Art Master at Devonport High School for Boys. He worked from a studio at his home in Ivybridge, Devon. He and his wife, Beryl, had two children. Beryl died in 1998.

During the 1950s Wyn George carried out two major public commissions: the mural in Plymouth Guildhall, and a mural for the children's library in the Central Library in Plymouth.